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Dtsch Med Wochenschr 2003; 128(44): 2319-2323
DOI: 10.1055/s-2003-43190
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Endokrinologie
© Georg Thieme Verlag Stuttgart · New York

Bedeutung des viszeralen Fettgewebes für das metabolische Syndrom

Visceral adipose tissue and metabolic syndromeM. Blüher1 , R. Paschke1
  • 1Medizinische Klinik und Poliklinik III, (komm. Direktor: Prof. Dr. R. Paschke) und Nachwuchsgruppe N03, IZKF Leipzig, Universität Leipzig
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Publication History

eingereicht: 24.4.2003

akzeptiert: 17.7.2003

Publication Date:
30 October 2003 (online)

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Zusammenfassung

Klinische und tierexperimentelle Untersuchungen haben gezeigt, dass das Fettverteilungsmuster das individuelle metabolische Risiko besser determiniert als die Gesamtkörperfettmasse. Es besteht eine positive Korrelation zwischen viszeraler Fettmasse und Insulinresistenz, metabolischem Syndrom, koronarem Herzkrankheits-Risiko sowie der hepatischen Glukoseproduktion. Die Beziehung zwischen Fettverteilungsmuster und Alter, Geschlecht, Energiehaushalt und mit metabolischen und genetischen Charakteristika wird diskutiert. Dabei werden Unterschiede in der Insulinsensitivität, der lipolytischen Aktivität, dem Glukosestoffwechsel und der endokrinen Regulation in Abhängigkeit von der Fettgewebslokalisation dargestellt. Die klinische Bedeutung einer differenzierten Charakterisierung der viszeral-betonten Adipositas besteht darin, Risikogruppen des Metabolischen Syndroms aufgrund molekularer und genetischer Marker der viszeralen Adipositas zu definieren und daraus Strategien zur Differenzialtherapie der Adipositas abzuleiten.

Summary

Epidemiological and animal studies often reported an association between increased visceral obesity and the prevalence of insulin resistance, type 2 diabetes, the risk of cardiovascular and cerebrovascular diseases and the hepatic glucose production. The correlation of fat distribution with age, gender energy balance and with metabolic and genetic characteristics are discussed. Especially, the differences in insulin sensitivity, lipolytic activity, glucose metabolism, and the endocrine regulation depending on the regional adipose tissue distribution are presented.

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Prof. Dr. med. R. Paschke

Universität Leipzig, Medizinische Klinik und Poliklinik III

Philipp-Rosenthal-Straße 27

04103 Leipzig

Phone: 0341/9713200

Fax: 0341/9713249

Email: pasr@medizin.uni-leipzig.de